L. Hudkins, Robert: search on Z-Library

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1

Pyrazole trk kinase inhibitors for the treatment of cancer

Hudkins, Robert L, Josef, Kurt A

Journal:

Expert Opinion on Therapeutic Patents

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

2

Characterization of Opioid Receptors

DeHaven, Robert N., DeHaven-Hudkins, Diane L.

Journal:

Current Protocols in Pharmacology

Year:

2000

Language:

english

File:

PDF, 118 KB

english, 2000

3

The Inflammatory Effect of Nucleus Pulposus

McCARRON, ROBERT F., WIMPEE, MARC W., HUDKINS, PHILIP G., LAROS, GERALD S.

Journal:

Year:

1987

File:

PDF, 502 KB

1987

4

Synthesis of the staurosporine aglycone (K-252c) lactam regioisomer

Robert L. Hudkins, James L. Diebold

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 196 KB

english, 1997

5

Synthesis and Mixed Lineage Kinase Activity of Pyrrolocarbazole and Isoindolone Analogs of (+)K-252a

Hudkins, Robert L., Johnson, Neil W., Angeles, Thelma S., Gessner, George W., Mallamo, John P.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

6

Tritiation of CEP-1347 at high specific activity using several methods

Judith A. Egan, Crist N. Filer, Scot Pounds, Thomas Connors, Ernest Knight Jr, Robert L. Hudkins

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2005

Language:

english

File:

PDF, 88 KB

english, 2005

7

Enzyme-Linked Immunosorbent Assay for trkA Tyrosine Kinase Activity

Thelma S. Angeles, Catherine Steffler, Becky A. Bartlett, Robert L. Hudkins, Robert M. Stephens, David R. Kaplan, Craig A. Dionne

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 151 KB

english, 1996

8

Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists

Virendra Kumar, Deqi Guo, Joel A. Cassel, Jeffrey D. Daubert, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Erin K. Gauntner, Susan L. Gottshall, Susan L. Greiner, Michael Koblish, Patrick J. Little, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

9

ChemInform Abstract: Synthesis and Evaluation of a New Series of 1′-Cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4′-piperidine] Derivatives as High Affinity and Selective Histamine-3 Receptor (H3R) Antagonists.

Reddeppa Reddy Dandu, Jacquelyn A. Lyons, Rita Raddatz, Zeqi Huang, Lisa D. Aimone, Robert L. Hudkins

Journal:

Year:

2012

File:

PDF, 28 KB

2012

10

Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists

Nadine C. Becknell, Jacquelyn A. Lyons, Lisa D. Aimone, John A. Gruner, Joanne R. Mathiasen, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 993 KB

english, 2011

11

The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor

Diane L. DeHaven-Hudkins, Robert N. DeHaven, Patrick J. Little, Lee M. Techner

Journal:

Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 429 KB

english, 2008

12

Fused Pyrrolo[2,3- c ]carbazol-6-ones: Novel Immunostimulants That Enhance Human Interferon-γ Activity

Hudkins, Robert L., Diebold, James L., Angeles, Thelma S., Knight, Ernest

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 167 KB

english, 1997

13

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models

Hudkins, Robert L., Diebold, James L., Tao, Ming, Josef, Kurt A., Park, Chung Ho, Angeles, Thelma S., Aimone, Lisa D., Husten, Jean, Ator, Mark A., Meyer, Sheryl L., Holskin, Beverly P., Durkin, John

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 751 KB

english, 2008

14

Recent Advances in Targeting the Fatty Acid Biosynthetic Pathway using Fatty Acid Synthase Inhibitors

Angeles, Thelma S., Hudkins, Robert L.

Journal:

Expert Opinion on Drug Discovery

Year:

2016

Language:

english

File:

PDF, 948 KB

english, 2016

15

Arylacetamides as peripherally restricted kappa opioid receptor agonists

Virendra Kumar, Michael A. Marella, Luz Cortes-Burgos, An-Chih Chang, Joel A. Cassel, Jeffrey D. Daubert, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Susan L. Gottshall, Erik Mansson, Alan L. Maycock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

16

Muscarinic receptor binding profile of para-substituted caramiphen analogs

Hudkins, Robert L., DeHaven-Hudkins, Diane L., Stubbins, James F.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 893 KB

english, 1991

17

TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs

Ted L. Underiner, Bruce Ruggeri, Lisa Aimone, Mark Albom, Thelma Angeles, Hong Chang, Robert L. Hudkins, Kathryn Hunter, Kurt Josef, Candy Robinson, Linda Weinberg, Shi Yang, Allison Zulli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 597 KB

english, 2008

18

Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Gabriel. J. Stabley, Robert N. DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

19

A Radioactive Binding Assay for Inhibitors of trkA Kinase

Ernest Knight Jr., Thomas J. Connors, Anna C. Maroney, Thelma S. Angeles, Robert L. Hudkins, Craig A. Dionne

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 122 KB

english, 1997

20

4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists

Robert L. Hudkins, Lisa D. Aimone, Reddeppa reddy Dandu, Derek Dunn, John A. Gruner, Zeqi Huang, Kurt A. Josef, Jacquelyn A. Lyons, Joanne R. Mathiasen, Ming Tao, Allison L. Zulli, Rita Raddatz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 699 KB

english, 2012

21

Discovery and Characterization of 6-{4-[3-( R )-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2 H -pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H 3 Receptor Inverse Agonist

Hudkins, Robert L., Raddatz, Rita, Tao, Ming, Mathiasen, Joanne R., Aimone, Lisa D., Becknell, Nadine C., Prouty, Catherine P., Knutsen, Lars J. S., Yazdanian, Mehran, Moachon, Gilbert, Ator, Mark A.,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1007 KB

english, 2011

22

Novel (4-Phenylpiperidinyl)- and (4-Phenylpiperazinyl)alkyl-Spaced Esters of 1-Phenylcyclopentanecarboxylic Acids as Potent .sigma.-Selective Compounds

Hudkins, Robert L., Mailman, Richard B., DeHaven-Hudkins, Diane L.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1011 KB

english, 1994

23

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 42 Volume 42 || Chapter 4 Recent Advances in Drug Discovery of Histamine H3 Antagonists

Hudkins, Robert L.

Year:

2007

Language:

english

File:

PDF, 159 KB

english, 2007

24

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Bertrand Le Bourdonnec, Christopher W. Ajello, Pamela R. Seida, Roberta G. Susnow, Joel A. Cassel, Serge Belanger, Gabriel J. Stabley, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

25

Synthesis and evaluation of 4-alkoxy-[1′-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4′-piperidine)] analogues as histamine-3 receptor antagonists

Nadine C. Becknell, Reddeppa Reddy Dandu, Jacquelyn A. Lyons, Lisa D. Aimone, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

26

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Allison L. Zulli, Lisa D. Aimone, Joanne R. Mathiasen, John A. Gruner, Rita Raddatz, Edward R. Bacon, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 686 KB

english, 2012

27

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

Ghose, Arup K., Herbertz, Torsten, Hudkins, Robert L., Dorsey, Bruce D., Mallamo, John P.

Journal:

ACS Chemical Neuroscience

Year:

2012

Language:

english

File:

PDF, 3.74 MB

english, 2012

28

Synthesis of 1H-Indolyl-2-benzimidazoles and 1H-Indolyl-2-benzothiazoles

L. Hudkins, Robert

Journal:

Year:

1995

Language:

english

File:

PDF, 146 KB

english, 1995

29

Amino acid conjugates as κ opioid receptor agonists

Virendra Kumar, Deqi Guo, Jeffrey D. Daubert, Joel A. Cassel, Robert N. DeHaven, Erik Mansson, Diane L. DeHaven-Hudkins, Alan L. Maycock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

30

High specific activity tritiation of the pyridazin-3-one histamine H3 receptor inverse agonist CEP-27088

Joseph R. Andrews, Crist N. Filer, Mario Maniscalco, Nadine C. Becknell, Robert L. Hudkins

Journal:

Applied Radiation and Isotopes

Year:

2012

Language:

english

File:

PDF, 238 KB

english, 2012

31

Synthesis of Indeno[2,1-a]pyrrolo[3,4-c]carbazole Lactam Regioisomers Using Ethyl cis-β-Cyanoacrylate as a Dienophile and Lactam Precursor.

Robert L. Hudkins, Chung Ho Park

Journal:

Year:

2003

File:

PDF, 196 KB

2003

32

8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors

Robert L. Hudkins, Allison L. Zulli, Ted L. Underiner, Thelma S. Angeles, Lisa D. Aimone, Sheryl L. Meyer, Daniel Pauletti, Hong Chang, Elena V. Fedorov, Steven C. Almo, Alexander A. Fedorov, Bruce A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 346 KB

english, 2010

33

Synthesis and structure–activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists

Ming Tao, Rita Raddatz, Lisa D. Aimone, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 854 KB

english, 2011

34

Serum amyloid A and inflammation in diabetic kidney disease and podocytes

Anderberg, Robert J, Meek, Rick L, Hudkins, Kelly L, Cooney, Sheryl K, Alpers, Charles E, Leboeuf, Renee C, Tuttle, Katherine R

Journal:

Laboratory Investigation

Year:

2015

Language:

english

File:

PDF, 44 KB

english, 2015

35

ChemInform Abstract: 8-THP-DHI Analogues as Potent Type I Dual TIE-2/VEGF-R2 Receptor Tyrosine Kinase Inhibitors.

Robert L Hudkins, et al. et al.

Journal:

Year:

2010

File:

PDF, 19 KB

2010

36

Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists

Nadine C. Becknell, Jacquelyn A. Lyons, Lisa D. Aimone, Zeqi Huang, John A. Gruner, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

37

Editorial [Hot topic: Current Approaches for the Treatment of Cognitive Deficits in CNS Disease (Guest Editor: Robert L. Hudkins)]

Hudkins, Robert

Journal:

Current Topics in Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 32 KB

english, 2010

38

Synthesis and biological evaluation of iodine-125 iodocaramiphen. A potential M1 muscarinic imaging agent for SPECT

Daniel W. McPherson, F. F. (Russ) Knapp Jr., Robert L. Hudkins

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1994

Language:

english

File:

PDF, 376 KB

english, 1994

39

The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

David P. Rotella, Marcie A. Glicksman, J.Eric Prantner, Nicola T. Neff, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 198 KB

english, 1995

40

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 166 KB

english, 2005

41

Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives

Robert L. Hudkins, Diane L. DeHaven-Hudkins, Peter Doukas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 339 KB

english, 1997

42

Synthesis and structure–activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H3 receptor inverse agonists

Ming Tao, Lisa D. Aimone, John A. Gruner, Joanne R. Mathiasen, Zeqi Huang, Jacquelyn Lyons, Rita Raddatz, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 358 KB

english, 2012

43

Anticonvulsant activity of caramiphen analogs

Diane L. Dehaven-Hudkins, J.Tim Allen, Robert L. Hudkins, James F. Stubbins, Frank C. Tortella

Journal:

Year:

1995

Language:

english

File:

PDF, 435 KB

english, 1995

44

Synthesis Of 2-Aryl- and 2-Vinyl-1H-indoles via Palladium-Catalyzed Cross-Coupling of Aryl and Vinyl Halides with 1-Carboxy-2-(tributylstannyl)indole

Hudkins, Robert L., Diebold, James L., Marsh, Frank D.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 371 KB

english, 1995

45

Synthesis, Modeling, and In Vitro Activity of (3‘ S )- e pi -K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Gingrich, Diane E., Yang, Shi X., Gessner, George W., Angeles, Thelma S., Hudkins, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 416 KB

english, 2005

46

Serum amyloid A and inflammation in diabetic kidney disease and podocytes

Anderberg, Robert J, Meek, Rick L, Hudkins, Kelly L, Cooney, Sheryl K, Alpers, Charles E, Leboeuf, Renee C, Tuttle, Katherine R

Journal:

Laboratory Investigation

Year:

2015

Language:

english

File:

PDF, 3.81 MB

english, 2015

47

Overview: Recent Advances in the Medicinal Chemistry of Cannabinoids

Hudkins, Robert L, D'Ambra, Thomas E

Journal:

Expert Opinion on Therapeutic Patents

Year:

1993

Language:

english

File:

PDF, 1.04 MB

english, 1993

48

Regioselective synthesis of 2-methyl-2,5,6,11,12,13-hexahydro 4H indazolo[5,4-a]pyrrolo[3,4-c]carbazole-4-ones

Ming Tao, Chung Ho Park, Kurt Josef, Robert L. Hudkins

Journal:

Journal of Heterocyclic Chemistry

Year:

2009

Language:

english

File:

PDF, 109 KB

english, 2009

49

Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors

Nadine C. Becknell, Allison L. Zulli, Thelma S. Angeles, Shi Yang, Mark S. Albom, Lisa D. Aimone, Candy Robinson, Hong Chang, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 125 KB

english, 2006

50

Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity

Robert L. Hudkins, Lisa D. Aimone, Thomas R. Bailey, Robert J. Bendesky, Reddeppa reddy Dandu, Derek Dunn, John A. Gruner, Kurt A. Josef, Yin-Guo Lin, Jacquelyn Lyons, Val R. Marcy, Joanne R. Mathiase

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 361 KB

english, 2011

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